A. John Camm's Acquired Long QT Syndrome PDF

By A. John Camm

ISBN-10: 1405118385

ISBN-13: 9781405118385

ISBN-10: 1405146168

ISBN-13: 9781405146166

Lately there was substantial curiosity within the prognosis and realizing of ventricular repolarisation, relatively the QT period prolongation and irregular T and T/U wave morphology linked to torsades de pointes. Advances in ion channel cloning have vastly more advantageous our knowing of the position of ionic channels in mediating cardiac repolarisation. regrettably, it really is more and more regarded variety of medications, either these linked to changing repolarisation, and others for non-cardiac stipulations can raise the propensity for polymorphic ventricular tachycardia, syncope or even ventricular traumatic inflammation and unexpected death.In this quantity, arrhythmia experts from St. George’s health facility clinical college, London talk about the mechanisms in the back of QT prolongation and torsades de pointes. They concentration quite at the probability of person cardiac and non-cardiac medicines in frightening lengthy QT syndrome, delivering a accomplished assessment so as to be beneficial for all electrophysiologists treating polymorphic ventricular tachycardias, and should reveal vital regulatory matters for pharmaceutical experts and for the broader clinical neighborhood.

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Extra resources for Acquired Long QT Syndrome

Sample text

Do mutations in cardiac ion channel genes predispose to drug-induced (acquired) long QT syndrome? Circulation 1997; 96 (Suppl. I): (Abstract): I-211. 34 Napolitano C, Schwartz P, Brown AM et al. Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Electrophysiol 2000; 11 (6): 691–6. 35 Vincent GM, Timothy KW, Leppert M, Keating M. The spectrum of symptoms and QT intervals in carriers of the gene fro the long QT syndrome.

Some workers, however, reported that both automatic and manual methods (using digitizing board) provided similar values [16]. With the manual method, the recording technology plays an important role for the precision of QT interval measurement. In the past, electrocardiograms were normally recorded only on paper using most frequently the standard 25 mm/s paper speed and 10 mm/mV gain. From ECGs recorded in this way, the QT interval was sometime measured using procedures of questionable precision including the use of hand-held callipers.

Furthermore, the normal ranges of QT interval using this technique may differ from those established for standard 12-lead recordings [25]. Depending on the leads selected, Holter measurements of QT intervals could range from 55 ms longer to 100 ms shorter (lead V1), or from 62 ms longer to 42 ms shorter (lead V5) than values obtained using standard 12-lead ECG [25]. With advances in electrocardiographic equipment, the possibility of recording 12-lead electrocardiograms digitally has occurred. , one sample every 2 ms leading to a theoretic measurement precision of + 1 ms).

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Acquired Long QT Syndrome by A. John Camm

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