By Samols D., Agrawal A., Kushner I.
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Extra resources for Acute Phase Proteins
The ratio of (k1 /k0 ) 1, the maximum in drug plasma concentration increases and the time to reach this maximum is shortened. This maximum needs to be determined, since any drug can be toxic at high concentrations. The absorption rate can be controlled by administration procedures. The current model reﬂects either an oral or intramuscular injection with a known release/absorption rate. A delta (δ) function can be used for the initial condition for the drug concentration in the body to simulate a rapid intravenous injection (referred to as bolus).
New strategies for increasing the permeability of brain capillaries to drugs are therefore frequently proposed. For example, transient increases in BBB permeability can be accomplished by intra-arterial injection of hyperosmolar solutions that disrupt endothelial plate junctions. Unfortunately, osmotically induced BBB disruptions affect capillary permeability throughout the CNS, enhancing permeability to all compounds not just the agent of interest. Other methods take advantage of the fact that the BBB is generally permeable to lipid-soluble compounds that can diffuse through endothelial cell membranes.
Peattie The SLM itself was modeled as a heterogeneous surface with mass transfer and reaction occurring only at active sites on the surface; in this case, the transverse pores. At present, long-term stability and toxicity problems limit SLM applications in biomedical settings. However, their use in combination with ﬁxed-site carrier membranes as entrapping barriers has great potential and is an active research area. 2 Facilitated Transport via Fixed Carriers A theoretical analysis of the mechanism of diffusion through a membrane, using a ﬁxed carrier covalently bound to the solid matrix, has been described elsewhere [7, 50].
Acute Phase Proteins by Samols D., Agrawal A., Kushner I.