Urs von Stockar (Editor), Luuk van der Wielen (Editor)'s Advances in Biochemical Engineering & Biotechnology, Volume PDF

By Urs von Stockar (Editor), Luuk van der Wielen (Editor)

ISBN-10: 3540436308

ISBN-13: 9783540436300

Strategy integration has been probably the most energetic learn fields in Biochemical Engineering over the past decade and it'll remain so if bioprocessing is to turn into extra rational, effective and efficient. This quantity outlines what has been accomplished lately. Written by means of specialists who've made very important contributions to the eu technology, starting place application on technique Integration in Biochemical Engineering, the quantity specializes in the growth made and the key possibilities, and likewise at the boundaries and the demanding situations in bioprocess integration that lie forward. the idea that of bioprocess integration is handled at quite a few degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but additionally accounting for the combination of separation and mass move operations and biology, fluid dynamics and body structure, in addition to easy technological know-how and strategy expertise.

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Extra info for Advances in Biochemical Engineering & Biotechnology, Volume 080: Process Integration in Biochemical Engineering

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Schmalzriedt et al. the microorganism and the metabolite to be measured (perchloric acid solution: –20 °C; methanol: –70 °C; liquid nitrogen: –196 °C). Systematic investigations have indicated that the most important quenching effect is due to the low temperature. , unpublished results]. However, as far as the very fast and initial response of intracellular metabolites in the millisecond range is concerned – and this is the time span of interest for the dynamic situation in the bioreactor – this method shows an inherent limitation.

23 is responsible for the concomitant translocation and phosphorylation of several sugars across the cytoplasmatic membrane. Sugar phosphorylation and translocation of glucose appears to involve several phosphoproteins, intermediates, and phosphoryl transfer reactions. 57 Integration of Physiology and Fluid Dynamics Table 4. Kinetic expressions in the model of Saccharomyces cerevisiae Name Symbol Mechanism Alcohol dehydrogenase Adenylate kinase Aldolase ATP consumption for maintenance Epimerase Glycerol 3-phosphate dehydrogenase Glucose 6-phosphate dehydrogenase 6-Phosphogluconate dehydrogenase Glyceraldehyde 3-phosphate dehydrogenase Phosphoglycerate mutase Enolase Glycerol phosphatase Hexokinase adh adk aldo ATPs epi g3pdh g6pdh pgdh gapdh mutenol enol glyph hk Competitive Near equilibrium Ordered uni-bi Michaelis-Menten Near equilibrium Ordered bi-bi Competitive Competitive Michaelis-Menten, reversible Pyruvate carboxylase Pyruvate dehydrogenase Pyruvate decarboxylase Permease pc pdh pdc perm Phosphofructo 1-kinase Phosphoglucose isomerase pfk pgi Phosphoglucose mutase Pyruavate kinase Triosephosphate isomerase pgm pk tis Transketolase Pyruvate transport tk TRpyr Activator Inhibitor NAD ATP ATP Michaelis-Menten Rapid equilibrium random bi-bi Michaelis-Menten Allosteric Pi Michaelis-Menten, reversible Allosteric ADP, AMP ATP Michaelis-Menten, reversible Michaelis-Menten Allosteric FDP, ADP ATP Michaelis-Menten, reversible Near equilibrium Michaelis-Menten Elucidating the dynamics of this uptake system is an essential step to critically assess the reliability of approximations based on the unstructured Monod type of rate expression.

67¥10–3 m3 s–1. Tank configuration of Bombac et al. [39] can be characterized by a hindered coalescence behavior like many fermentation broths due to their high salt concentrations, the bubble diameter is determined by the local energy dissipation in the stirrer zone. 4 from bubble size data reported by Greaves and Barigou [42]. Figure 4 shows exemplarily simulated flow velocities for the gas and liquid phase. Figure 5 summarizes a comparison between simulated and predicted local values of the specific gas hold-up.

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Advances in Biochemical Engineering & Biotechnology, Volume 080: Process Integration in Biochemical Engineering by Urs von Stockar (Editor), Luuk van der Wielen (Editor)

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