By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play an enormous function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step approach: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated via numerous diversified hormones. The sodium channels additionally play an important function in a few sickness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range offers the 1st in-depth alternate of principles bearing on those sodium channels, their law and involvement in general and pathophysiological events. Key positive factors * Summarizes present country of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers principles on sodium channels and ailment
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Additional info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
1998). In vitro phosphorylation of the epithelial sodium channel. Proc. Natl. Acad. Sci. A. 95, 3301-3305. Silver, R. , Windhager, E. , and Palmer, L. G. (1993). Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of the Na pump. Am. J. Physiol. 264, F557-F564. Snyder, P. , McDonald, F. , Stokes, J. , and Welsh, M. J. (1994). Membrane topology of the amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 269,24379-24383. Snyder, P. , Price, M. , McDonald, F. , Adams, C.
Closed and open time amplitude histogram analysis of the wild-type and mutated channels in the presence of amiloride could be fitted with a double exponential, suggesting that the channel could have two open states (open and open-bound). However, because the open-bound state (accounting for the first exponent) was only observed at very low amiloride concentrations 20 C. M. Fuller et al. 2 pM for wt and <1 pM for the mutants) it is likely that at higher concentrations of amiloride, a single amiloride-bound state equivalent to an open-channel block is dominant.
Cloning of the amiloridesensitive FMRFamide peptide-gated sodium channel. Nature (London) 378, 730-733. , and Eaton, D. C. (1991). Effects of vasopressin and CAMPon single amilorideblockade Na channels. Am. J. Physiol. 260, C1071-C1084. Oh, Y . , Smith, P. R.. Bradford, A. , and Benos, D. J. (1993). Regulation by phosphorylation of purified epithelial Na channels in planar lipid bilayers. Am. J . Physiol. 265, C85-C91. Palmer, L. , and Frindt, G. (1986a). Amiloride-sensitive Na' channels from the apical membrane of the rat cortical collecting tubule.
Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)