By Lucinda L. Veeck, Nikica Zaninovic
Should you had a liable strategy for deciding upon the healthiest and such a lot workable conceptus from a cohort of becoming preembryos, changing greater than a unmarried one to be able to in achieving sturdy being pregnant premiums will be moot. someday within the not-so-distant destiny, this can be a truth. Taking a step in the direction of that destiny, An Atlas of Human Blastocysts vividly illustrates the common and strange morphology of mammalian blastocysts. The atlas demonstrates that prolonged tradition of blastocysts is now conceivable within the laboratory and issues us towards the day whilst will probably be attainable to select from a few fit hatched blastocysts.
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Extra info for An atlas of human blastocysts
Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization. Hum Reprod 1997; 12:1545–9 73. Wiemer KE, Dale B, Hu Y, Steuerwald N, Maxson WS, Hoffman Dl. Blastocyst development in co-culture: development and morphological aspects. Hum Reprod 1995; 10:3226–32 74. Shoukir Y, Campana A, Farley T, Sakkas D. Early cleavage of in-vitro fertilized human embryos to the 2-cell stage: a novel indicator of embryo quality and viability. Hum Reprod 1997; 12:1531–6 75.
Hum Reprod 1996; 11:1650–3 60. Palermo GD, Schlegel PN, Sills ES, et al. Births after intra-cytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaic Klinefelter’s syndrome. N Engl J Med 1998; 338:588–90 An atlas of human blastocysts 22 61. Van Blerkom J. Developmental failure in human reproduction associated with preovulatory oogenesis and preimplantation embryogenesis. In Van Blerkom J, Motta PM, eds. Ultrastructure of Human Gametogenesis and Early Embryogenesis; Electron Microscopy in Biology and Medicine 5.
In support of this, when mouse zygotes were cultured to the blastocyst in the absence of glucose, although resultant blastocysts implanted in the uterus after transfer, significantly more fetuses were lost compared with the control blastocysts which had developed in the presence of glucose59, indicating impaired ICM development or function. Significance of pyruvate and lactate to the embryo Pyruvate enters the embryo both passively and by means of a facilitated carrier28,44, and is the preferred nutrient of the cleavage stage embryo of several species, including the human5.
An atlas of human blastocysts by Lucinda L. Veeck, Nikica Zaninovic